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SLV-2436

Cat. No. M9474
SLV-2436 Structure
Synonym:

SEL-201

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

SLV-2436 (SEL201-88) is a novel ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively. SEL201 potently suppressed MNK1/2 activity in our panel of KIT-mutant melanoma cell lines, as determined by repressed phosphorylation of its substrate eIF4E. In addition, SEL201 significantly decreased the colony-forming ability of both C-KIT D820Y and L576P mutant melanoma cell lines.

Chemical Information
Molecular Weight 350.8
Formula C19H15ClN4O
CAS Number 2095704-43-9
Solubility (25°C) DMSO ≥ 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhan Y, et al. J Clin Invest. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

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Keywords: SLV-2436, SEL-201 supplier, MNK, inhibitors, activators


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