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SLV-2436 (SEL201-88) is a novel ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively. SEL201 potently suppressed MNK1/2 activity in our panel of KIT-mutant melanoma cell lines, as determined by repressed phosphorylation of its substrate eIF4E. In addition, SEL201 significantly decreased the colony-forming ability of both C-KIT D820Y and L576P mutant melanoma cell lines.
| Molecular Weight | 350.8 |
| Formula | C19H15ClN4O |
| CAS Number | 2095704-43-9 |
| Solubility (25°C) | DMSO ≥ 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MNK Products |
|---|
| DS12881479
DS12881479 is a potent and selective Mnk1 inhibitor with an IC50 value of 21 nM. |
| EB1
EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation. |
| MNK inhibitor 9
MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research. |
| ETC-206 (AUM 001)
ETC-206 is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively. |
| WAY-305025
WAY-305025 is a selective Mnk inhibitor. |
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Products are for research use only. Not for human use. We do not sell to patients.
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