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SGC3027

Cat. No. M13850
SGC3027 Structure
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Biological Activity

SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.

Chemical Information
Molecular Weight 787.37
CAS Number 2624313-13-7
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nivine Srour, et al. Cell Rep. PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

[2] Magdalena M Szewczyk, et al. Nat Commun. Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

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  Catalog
Abmole Inhibitor Catalog




Keywords: SGC3027 supplier, Histone Methyltransferase, inhibitors, activators


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