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SFTI-1

Cat. No. M40668

All AbMole products are for research use only, cannot be used for human consumption.

SFTI-1 Structure
Synonym:

Sunflower trypsin inhibitor 1

Size Price Availability Quantity
5mg USD 960  USD960 In stock
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Quality Control & Documentation
Biological Activity

SFTI-1 is a head-to-tail bicyclic peptide with a disulfide bond that inhibits the serine protease trypsin with subnanomolar levels of inhibition constants. It can be used as a protease inhibitor or as a molecular grafting scaffold. In addition, by introducing a known tetrapeptide pharmacophore into the bicyclic SFTI-1, a potent ligand for melanocortin can be created.

Chemical Information
Molecular Weight 1513.78
Formula C67H104N18O18S2
CAS Number 245080-24-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Thomas N G Handley et al. Methods Mol Biol. Scalable and Efficient In Planta Biosynthesis of Sunflower Trypsin Inhibitor-1 (SFTI) Peptide Therapeutics

[2] Simon J de Veer et al. Angew Chem Int Ed Engl. Sunflower Trypsin Inhibitor-1 (SFTI-1): Sowing Seeds in the Fields of Chemistry and Biology

[3] Yilong Li et al. Biopolymers. Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing

[4] Agata Gitlin et al. Chembiochem. Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1

[5] Michael L J Korsinczky et al. Curr Protein Pept Sci. Sunflower trypsin inhibitor-1

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Keywords: SFTI-1, Sunflower trypsin inhibitor 1 supplier, inhibitors, activators

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