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SF2312 

Cat. No. M27760

All AbMole products are for research use only, cannot be used for human consumption.

SF2312  Structure
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5mg USD 500  USD500 In stock
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Biological Activity

SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions.

Chemical Information
Molecular Weight 197.08
Formula C4H8NO6P
CAS Number 107729-45-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Muhammad Hassan, et al. Daru. Molecular docking of alpha-enolase to elucidate the promising candidates against Streptococcus pneumoniae infection

[2] Jolanta Krucinska, et al. Sci Rep. Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate

[3] Federica Pisaneschi, et al. Molecules. The 3 S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues

[4] Nikunj Satani, et al. PLoS One. ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase

[5] Paul G Leonard, et al. Nat Chem Biol. SF2312 is a natural phosphonate inhibitor of enolase

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D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalysed process of glycolysis.
POMHEX 

POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor.
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Keywords: SF2312  supplier, Enolase, inhibitors, activators

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