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Seribantumab

Cat. No. M24616

All AbMole products are for research use only, cannot be used for human consumption.

Seribantumab Structure
Synonym:

SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody

Size Price Availability
1mg USD 150  USD150 4-7 Days
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Quality Control & Documentation
Biological Activity

Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models.

Chemical Information
CAS Number 1334296-12-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Subotheni Thavaneswaran, et al. JCO Precis Oncol. Clinical Response to Seribantumab, an Anti-Human Epidermal Growth Factor Receptor-3 Immunoglobulin 2 Monoclonal Antibody, in a Patient With Metastatic Pancreatic Ductal Adenocarcinoma Harboring an NRG1 Fusion

[2] Crystal S Denlinger, et al. Invest New Drugs. Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors

[3] Igor Odintsov, et al. Clin Cancer Res. The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions

[4] Birgit Schoeberl, et al. NPJ Syst Biol Appl. Systems biology driving drυg development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)

[5] Michael D Curley, et al. Mol Cancer Ther. Seribantumab, an Anti-ERBB3 Antibody, Delays the Onset of Resistance and Restores Sensitivity to Letrozole in an Estrogen Receptor-Positive Breast Cancer Model

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Keywords: Seribantumab, SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody supplier, EGFR/HER2, inhibitors, activators

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