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Senkyunolide-H

Cat. No. M4426
Senkyunolide-H Structure
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20mg USD 1000  USD1000 Out of stock
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Quality Control & Documentation
Biological Activity

Senkyunolide H is a natural compound extracted from Ligusticum chuanxiong Hort.

Chemical Information
Molecular Weight 224.25
Formula C12H16O4
CAS Number 94596-27-7
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jun Tan, et al. Senkyunolide H inhibits activation of microglia and attenuates lipopolysaccharide-mediated neuroinflammation and oxidative stress in BV2 microglia cells via regulating ERK and NF-κB pathway

[2] Yunyao Jiang, et al. Senkyunolide H protects PC12 cells from OGD/R-induced injury via cAMP-PI3K/AKT signaling pathway

[3] Daishui Yang, et al. Senkyunolide H attenuates osteoclastogenesis and postmenopausal osteoporosis by regulating the NF-κB, JNK and ERK signaling pathways

[4] Yanyan Luo, et al. Senkyunolide H protects against MPP +-induced apoptosis via the ROS-mediated mitogen-activated protein kinase pathway in PC12 cells

[5] Yun Wei, et al. Preparative isolation and purification of senkyunolide-I, senkyunolide-H and ferulic acid from Rhizoma Chuanxiong using counter-current chromatography

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