Free shipping on all orders over $ 500

Salicin

Cat. No. M14084
Salicin Structure
Synonym:

D-(−)-Salicin; Salicoside

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Salicin is a natural COX inhibitor.

Chemical Information
Molecular Weight 286.28
CAS Number 138-52-3
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Joon-Ha Park, et al. Neuroprotective Effects of Salicin in a Gerbil Model of Transient Forebrain Ischemia by Attenuating Oxidative Stress and Activating PI3K/Akt/GSK3β Pathway

[2] Katarzyna Adamiak, et al. The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen

[3] Fei Guo, et al. Salicin prevents TNF-α-induced cellular senescence in human umbilical vein endothelial cells (HUVECs)

[4] Yu Song, et al. Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells

[5] Mohd Shara, et al. Efficacy and Safety of White Willow Bark (Salix alba) Extracts

Related COX Products
Birch triterpenes

Birch triterpenes is a cyclooxygenase-2 (COX-2) inhibitor that can be used in studies related to epidermolysis bullosa.

Naproxcinod

Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation.

Hamaudol

Hamaudol is a chromone isolated from Saposhnikovia divaricata.

(±)-Catechin

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin.

PYZ18

PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Salicin, D-(−)-Salicin; Salicoside supplier, COX, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.