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Saikosaponin b3

Cat. No. M17764
Saikosaponin b3 Structure
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Biological Activity

Saikosaponin b3

Chemical Information
CAS Number 58316-42-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kaiju Sun, et al. Theranostics. Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m 6 A signaling

[2] Chun Sui, et al. Curr Pharm Biotechnol. Recent Progress in Saikosaponin Biosynthesis in Bupleurum

[3] Junsong Jiang, et al. J Tissue Eng Regen Med. Saikosaponin D: A potential therapeutic drug for osteoarthritis

[4] Xiaojiaoyang Li, et al. Phytomedicine. A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins

[5] Zhi-An Du, et al. Inflammation. Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice

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