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Ganodermanontriol

Cat. No. M17749

All AbMole products are for research use only, cannot be used for human consumption.

Ganodermanontriol Structure
Size Price Availability Quantity
5mg USD 290  USD290 In stock
10mg USD 450  USD450 In stock
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Biological Activity

Ganodermanontriol is a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol inhibits breast cancer cell lines MCF-7 and MDA-MB-231with IC50 values of 5.8 and 9.7 μM, respectively. Ganodermanontriol exhibits hepatoprotective activity.

Chemical Information
Molecular Weight 472.7
Formula C30H48O4
CAS Number 106518-63-2
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chengkai Xu, et al. J Cancer Res Ther. Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma

[2] Do Thi Ha, et al. J Ethnopharmacol. In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress

[3] Erin M Kennedy, et al. J Nat Prod. Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols

[4] Jiahua Jiang, et al. Biochem Biophys Res Commun. Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA

[5] Andrej Jedinak, et al. Int J Oncol. Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling

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Keywords: Ganodermanontriol supplier, Triterpenoids, inhibitors, activators

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