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S107

Cat. No. M9272

All AbMole products are for research use only, cannot be used for human consumption.

S107 Structure
Synonym:

S107 free base

Size Price Availability Quantity
10mM*1mL USD 120  USD120 In stock
5mg USD 110  USD110 In stock
10mg USD 175  USD175 In stock
25mg USD 360  USD360 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

S107 binds RyR1 and enhances the binding affinity of calstabin-1. S107 inhibits Ca leak from the sarcoplasmic reticulum (SR). S107 increases FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. S107 can reverse the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites.

Chemical Information
Molecular Weight 209.31
Formula C11H15NOS
CAS Number 927871-76-9
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mei Y, et al. PLoS One. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107.

[2] Lehnart SE, et al. J Clin Invest. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

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Keywords: S107, S107 free base supplier, inhibitors, activators

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