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(S)-Sunvozertinib

Cat. No. M11417
(S)-Sunvozertinib  Structure
Synonym:

(S)-DZD9008;DZD9008

Size Price Availability Quantity
5mg USD 142.4  USD178 In stock
10mg USD 224  USD280 In stock
25mg USD 448  USD560 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

(S)-Sunvozertinib ((S)-DZD9008) is the S-enantiomer of Sunvozertinib, EGFR exon 20 NPH and ASV insertion, EGFR L858R/T790M mutation and Her2 exon 20 YVMA insertion (IC50 was 51.2 nM, 51.9 nM, 1 nM and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 584.08
Formula C29H35ClFN7O3
CAS Number 2370013-49-1
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C
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Keywords: (S)-Sunvozertinib , (S)-DZD9008;DZD9008 supplier, EGFR/HER2, inhibitors

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