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S-Gboxin, a functional analogue of Gboxin, is an oxidative phosphorylation (OXPHOS) inhibitor which inhibits growth of mouse and human glioblastoma (GBM) with IC50 of 470 nM.
S-Gboxin (10 mg/kg/day; intraperitoneally) inhibits glioblastoma (GBM) growth in vivo. S-Gboxin retains excellent metabolic stability, enhanced plasma stability, and PK-properties suitable for in vivo studies.
| Molecular Weight | 600.45 |
| Formula | C27H32F3IN2O2 |
| CAS Number | 2101317-21-7 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | -20°C, sealed |
[1] Yan Wang, et al. Nat Commun. ZFP281-BRCA2 prevents R-loop accumulation during DNA replication
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