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S-Adenosylhomocysteine, an intermediate in the synthesis of cysteine and adenosine, is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.
Mol Nutr Food Res. 2023 Feb 3;e2101052.
Oxidative Stress Mediated by N6‐Methyladenosine Methylation Contributes to High‐Fat Diet Induced Male Reproductive Dysfunction
S-Adenosylhomocysteine purchased from AbMole
| Molecular Weight | 384.41 |
| Formula | C14H20N6O5S |
| CAS Number | 979-92-0 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[3] Joy Xin Wang, et al. Riboswitches that sense S-adenosylmethionine and S-adenosylhomocysteine
| Related METTL3 Products |
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UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. |
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METTL3-IN-4 is a METTL3 inhibitor. |
| STM2120
STM2120 is a METTL3-METTL14 inhibitor with an IC50 of 64.5 μM. |
| 7OQL
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