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S-adenosyl-l-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the main biomethyl donor synthesized in all mammalian cells, but is most abundant in liver. Ademetionine has anti-inflammatory activity and has been used in studies of chronic liver disease.
| Molecular Weight | 766.79 |
| Formula | C22H34N6O16S4 |
| CAS Number | 97540-22-2 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 50 mg/mL Water 30 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related Metabolite/Endogenous Metabolite Products |
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| Dihydrothymine
Dihydrothymine (5,6-Dihydro-5-methyluracil) is an intermediate breakdown product of thymine, comes from animal or plants. |
| Myristoyl coenzyme A lithium
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms. |
| Lithium acetoacetate
Lithium acetoacetate (Acetoacetic acid lithium) is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Lithium acetoacetate induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. |
| Gentisuric Acid
Gentisuric Acid is a metabolite of Aspirin, it is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C. |
| 5α-Dihydroprogesterone
5α-Dihydroprogesterone (5a-Pregnane-3,20-dione) is the endogenous progesterone metabolite. 5α-Dihydroprogesterone (5a-Pregnane-3,20-dione) decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerizes F-actin in MCF-7 breast cancer cells. |
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