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(S)-3-Hydroxybutanoic acid

Cat. No. M10133
(S)-3-Hydroxybutanoic acid Structure
Size Price Availability Quantity
50mg USD 55  USD55 In stock
100mg USD 85  USD85 In stock
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Biological Activity

(S)-3-Hydroxybutanoic acid is a human metabolite.

Chemical Information
Molecular Weight 104.1
Formula C4H8O3
CAS Number 6168-83-8
Solubility (25°C) Water 50 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Grażyna Adamus, et al. Polymers (Basel). From Anionic Ring-Opening Polymerization of β-Butyrolactone to Biodegradable Poly(hydroxyalkanoate)s: Our Contributions in This Field

[2] Tina Hinton, et al. Bioorg Med Chem Lett. Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors

[3] Z G Arkin, et al. J Biomater Sci Polym Ed. Water-soluble L-alanine and related oligopeptide conjugates with poly[(R,S)-3-hydroxybutanoic acid] oligomers, synthesis and structural studies by means of electrospray ionization multistage mass spectrometry

[4] S Das, et al. Proc Natl Acad Sci U S A. Proof for a nonproteinaceous calcium-selective channel in Escherichia coli by total synthesis from (R)-3-hydroxybutanoic acid and inorganic polyphosphate

[5] S Miyamoto, et al. Yakugaku Zasshi. [Resolution of (3RS)-4-amino-3-hydroxybutanoic acid (author's transl)]

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