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RU-302 

Cat. No. M27894

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RU-302  Structure
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Biological Activity

RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth.

Chemical Information
Molecular Weight 475.53
Formula C24H24F3N3O2S
CAS Number 1182129-77-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Edita Sarukhanyan, et al. ACS Omega. In Silico Designed Axl Receptor Blocking Drυg Candidates Against Zika Virus Infection

[2] Stanley G Kimani, et al. Sci Rep. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity

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  Catalog
Abmole Inhibitor Catalog




Keywords: RU-302  supplier, TAM Receptor, inhibitors, activators

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