Rose Bengal is a red or rose color dye and is anionic in nature. It is a 4,5,6,7-tetrachloro 2′,4′,5′,7′-tetraiodo derivative of fluorescein. It is widely used to detect damage to the ocular surface epithelium in ocular surface diseases such as dry eye and herpetic keratitis. Rose Bengal has mild antiviral potency. Rose Bengal is used to stain dead and degenerating cells and mucus. Rose Bengal has been used to evaluate acrosome integrity. It has also been used to initiate photothrombotic occlusion in blood.
|Solubility (25°C)||Water 30 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Shailja Kumar, et al. Eur J Pharm Sci. Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications
 Michael J Doughty, et al. Cont Lens Anterior Eye. Fluorescence characteristics of sodium fluorescein-rose bengal ophthalmic solution mixtures
 Juan Murube. Ocul Surf. Rose bengal: the second most commonly used surfocular vital stain
 M I Roat, et al. Arch Ophthalmol. The antiviral effects of rose bengal and fluorescein
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