Rose Bengal is a red or rose color dye and is anionic in nature. It is a 4,5,6,7-tetrachloro 2′,4′,5′,7′-tetraiodo derivative of fluorescein. It is widely used to detect damage to the ocular surface epithelium in ocular surface diseases such as dry eye and herpetic keratitis. Rose Bengal has mild antiviral potency. Rose Bengal is used to stain dead and degenerating cells and mucus. Rose Bengal has been used to evaluate acrosome integrity. It has also been used to initiate photothrombotic occlusion in blood.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water 30 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
|Related Fluorescent Dye Products|
Lyso-Tracker Red is an eosinophilic fluorescent probe with a maximum excitation wavelength of 577nm and a maximum emission wavelength of 590nm. Lyso-Tracker Red must be at very low concentrations (usually about 50nM) to achieve excellent selectivity.
|FITC-Dextran (MW 10000)
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm).
ICG-OSu (ICG NHS ester) is a near infrared fluorescent agent with amine reactivity that is widely used in the design of in vivo imaging probes. Em >750 nm infrared, Ex >750 nm infrared.
FITC-Dextran is a marker consisting of coupling fluorescein-isothiocyanate to dextran.
|Cyanine 5 maleimide
Cy5 maleimide is a fluorescent dye and various cyanidin 5 (Cy5) dyes have been used to label biomolecules for fluorescent imaging and other fluorescence-based biochemical analyses. They are widely used to label peptides, proteins, and oligonucleotides, among others. The maximum excitation/emission wavelength is 651/670 nm.
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