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Rose Bengal

Cat. No. M15100
Rose Bengal Structure
Synonym:

Acid Red 94

Size Price Availability Quantity
1g USD 48  USD60 In stock
5g USD 160  USD200 In stock
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Quality Control
  • Current batch:
  • Purity 95%
  • COA
  • MSDS
Biological Activity

Rose Bengal is a red or rose color dye and is anionic in nature. It is a 4,5,6,7-tetrachloro 2′,4′,5′,7′-tetraiodo derivative of fluorescein. It is widely used to detect damage to the ocular surface epithelium in ocular surface diseases such as dry eye and herpetic keratitis. Rose Bengal has mild antiviral potency. Rose Bengal is used to stain dead and degenerating cells and mucus. Rose Bengal has been used to evaluate acrosome integrity. It has also been used to initiate photothrombotic occlusion in blood.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 997.66
Formula C20H5Cl4I4NaO5
CAS Number 632-69-9
Purity 95%
Solubility Water 30 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Shailja Kumar, et al. Eur J Pharm Sci. Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications

[2] Michael J Doughty, et al. Cont Lens Anterior Eye. Fluorescence characteristics of sodium fluorescein-rose bengal ophthalmic solution mixtures

[3] Juan Murube. Ocul Surf. Rose bengal: the second most commonly used surfocular vital stain

[4] M I Roat, et al. Arch Ophthalmol. The antiviral effects of rose bengal and fluorescein

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