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RNase A, bovine pancreas cleaves RNA 3' to pyrimidines and cleaves RNA at each pyrimidine residue.Ribonuclease A catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors. RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability.
One unit is defined as the amount of enzyme that an increase in absorbance of 0.001 at 260 nm in 1 min at 50°C and pH 5.0, using 1.5 mL yeast RNA at 0.15 mg/mL as substrate.
| CAS Number | 9001-99-4 |
| Form | Solid |
| Solubility (25°C) | Water 90 mg/mL |
| Storage | Store at -20°C for 2 years |
| Related Nucleic Acid Extraction and Purification Products |
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| CTAB
Cetrimonium Bromide is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts. |
| Chicken egg albumin (agarose gel electrophoresis)
Chicken egg albumin, or ovalbumin, is the major protein constituent of egg whites. Ovalbumin is useful as a marker (∼45 kDa) for protein electrophoresis. Ovalbumin has been used to produce an animal model of asthma. Ovalbumin was used as a medium for cell incubation in EliCell assay for the detection of released cytokines from eosinophils. Studies to test the effects of localization on DNA immunizations use ovalbumin in antibody assays. Ovalbumin has been used as an induction agent in model studies of atopic dermatitis. |
| T7 RNA Polymerase (E. coli)
T7 RNA polymerase is a DNA-dependent RNA polymerase that specifically recognizes the T7 promoter sequence (5' -TaatacgactCactatagggaga-3 ') and has high specificity for the phage T7 promoter sequence. T7 RNA polymerase can catalyze NTP incorporation of single or double stranded DNA template downstream of T7 promoter to synthesize RNA complementary to the downstream DNA template of T7 promoter. |
| Recombinant RNase Inhibitor
RNase Inhibitor is a recombinant protein of murine origin expressed in E.coli, which specifically inhibits RNase A, B and C by binding noncovalently in a 1:1 ratio with high affinity. |
| Recombinant RNase R
Recombinant RNase R (E. coli) is a magnesium-dependent 3′→5′ exoribonuclease that can digest all linear RNAs but does not digest lariat or circular RNA structures. Most cellular RNAs will be digested completely by RNase R, with the exception of tRNAs, 5S RNA and intron lariats. |
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