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Revaprazan Hydrochloride

Cat. No. M20452
Revaprazan Hydrochloride Structure
Synonym:

YH1885

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Biological Activity

Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects.

Chemical Information
Molecular Weight 398.90
Formula C22H24ClFN4
CAS Number 178307-42-1
Solubility (25°C) DMSO 16 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jung Sunwoo, et al. Aliment Pharmacol Ther. Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects

[2] Young-Min Han, et al. Biochem Pharmacol. Revaprazan prevented indomethacin-induced intestinal damages by enhancing tight junction related mechanisms

[3] Jong Hyuck Park, et al. Pharm Dev Technol. Revaprazan-loaded surface-modified solid dispersion: physicochemical characterization and in vivo evaluation

[4] Jung Suk Kim, et al. J Microencapsul. Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability

[5] Jong Hyuck Park, et al. Colloids Surf B Biointerfaces. Comparison of a revaprazan-loaded solid dispersion, solid SNEDDS and inclusion compound: Physicochemical characterisation and pharmacokinetics

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Keywords: Revaprazan Hydrochloride, YH1885 supplier, Proton Pump, inhibitors, activators


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