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Retrorsine

Cat. No. M10008

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Retrorsine Structure
Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

Retrorsine is a naturally occurring pyrrolizidine alkaloid, which binds with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine significantly reduces HSEC-CYP3A4 cells viability, depletes GSH, and increases formation of pyrrole-protein adducts. Retrorsine (30 mg/kg; i.p.) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle.

Chemical Information
Molecular Weight 351.39
Formula C18H25NO6
CAS Number 480-54-6
Solubility (25°C) Soluble in CHCL3
Storage -20°C, dry, sealed, protect from light
References

[1] Yao Lu, et al. J Environ Sci Health C Toxicol Carcinog. Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids

[2] F J Cubero, et al. Cell Prolif. Hepatic proliferation in Gunn rats transplanted with hepatocytes: effect of retrorsine and tri-iodothyronine

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