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Recombinant Human Transferrin (Mammalian, C-6His)

Cat. No. M21471
Recombinant Human Transferrin (Mammalian, C-6His) Structure
Synonym:

Serotransferrin; Transferrin; Beta-1 metal-binding globulin

Size Price Availability Quantity
10ug USD 128  USD128 In stock
50ug USD 265  USD265 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Endotoxin: LAL test measured less than 0.1 ng/µg (1eu /µg)
Molecular weight: 76.2 KDa
Storage and stability: The freeze-dried protein should be stored at ≤-20°C for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The bisector of the recombinant sample was stable at ≤-20°C for 3 months.


Biological activity: Serum transferrin belongs to the transferrin family and contains two transferrin like domains. This protein is a secreted protein, expressed by the liver and secreted in the plasma. Transferrin is an iron-bound transporter that can bind two Fe3+ ions and bind to one anion. It is responsible for transporting iron from where it is absorbed and heme is degraded to where it is stored and used. Serum transferrin may also have a further role in stimulating cell proliferation.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T V Bobik, et al. Bull Exp Biol Med. Production of Recombinant Human Transferrin in Eukaryotic Pichia pastoris Expression System

[2] Martin E Brandsma, et al. Biotechnol Adv. Recombinant human transferrin: beyond iron binding and transport

[3] Deshui Zhang, et al. Protein Expr Purif. Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.)

[4] Kimihiko Mizutani, et al. Biosci Biotechnol Biochem. Structural and functional characterization of recombinant human serum transferrin secreted from Pichia pastoris

[5] Peter J Sargent, et al. Biometals. Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae

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Keywords: Recombinant Human Transferrin (Mammalian, C-6His), Serotransferrin; Transferrin; Beta-1 metal-binding globulin supplier, Recombinant Proteins, inhibitors, activators


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