Genus: Human
Expression system: E.coli
Purity: >95% by reduced SDS-PAGE
Molecular weight: 11 KDa
Endotoxin: <0.1 ng/µg (1 EU/µg) by LAL test
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Recombinant sample aliquots are stable for 3 months at <-20°C.
Bioactivity: Brain-type natriuretic peptide (BNP) is a non-glycosylated peptide produced mainly by ventricular myocytes and belongs to the natriuretic peptide family. 12 kDa of BNP precursor is proteolytically cleaved to produce N-terminal pro-BNP (NT-proBNP) and mature BNP. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a useful marker of heart failure (HF). Thought to be secreted primarily from the ventricles, increases in serum NT-proBNP levels are also encountered in conditions such as atrial fibrillation (AF) and atrial septal defects in patients without HF.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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