Genus: Human
Expression system: E.coli
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 14.2 KDa
Storage and stability: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C and stable for 3 months after opening under sterile conditions. Please minimize the freeze-thaw cycle.
Biological activity: Human natriuretic peptide B acts as a cardiac hormone; it is associated with many biological actions such as diuretic, diaphoretic, vasodilator and it inhibits the secretion of ranibulin and aldosterone. It acts as a paracrine antifibrotic factor in the heart. Natriuretic peptide B can help restore the balance of salt and water in the body and improve cardiac function. Natriuretic peptide B binds to the NPR1 receptor and stimulates the production of cGMP, which binds to the clearance receptor NPR3.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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