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Lymphocyte activation gene 3 protein (LAG3) is a member of immunoglobulin (Ig) superfamily. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. It can lead to increased antigen-specific T-cell responses in vivo.
Recombinant Human LAG-3 expressed the target gene encoding Met1-Leu450 with the Fc region of human IgG1 at the C-terminus.
Immobilized LAG3 Protein at 2 μg/mL (100 μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40ng/mL.
Accession: P18627
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 84.19 KDa, reducing conditions
Lyophilized from sterile 20mM NaH2PO4, 150mM NaCl, 0.1M Arg, 0.1M Glu, 10% glycerol, 0.01% tween20, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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