Free shipping on all orders over $ 500

Recombinant Human FGF-10/KGF-2 (E. coli)

Cat. No. M10353
Recombinant Human FGF-10/KGF-2 (E. coli) Structure
Synonym:

FGFA, Keratinocyte growth factor-2

Size Price Availability Quantity
10ug USD 144  USD160 In stock
50ug USD 396  USD440 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Human Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development. Recombinant Human FGF-10 produced in E. coli is a single, non-glycosylated polypeptide chain containing 169 amino acids. 

ED50 < 20 ng/mL, measured by a cell proliferation assay using 4 MBr-5 cells, corresponding to a specific activity of > 5.0 × 104 units/mg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 0.2 EU/μg
Solubility Reconstituted in ddH2O at 100 μg/ml
Storage at -20°C
Related Cytokines Products
Recombinant Mouse Interleukin-4 (IL-4) (E. coli)

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression.

Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed)

Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression.

Recombinant Rat Insulin-like Growth Factor-1 (E. coli)

Recombinant Rat Insulin-like Growth Factor-1 belonged to the insulin gene family, it is mitogenic polypeptide growth factor that stimulates the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro.

Recombinant Human TGF-α (E. coli)

Recombinant Human TGF-α, also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells.

Recombinant Human EGF (E. coli)

Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Human FGF-10/KGF-2 (E. coli), FGFA, Keratinocyte growth factor-2 supplier, Cytokines, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.