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Recombinant Human FGF-10/KGF-2 (E. coli)

Cat. No. M10353
Recombinant Human FGF-10/KGF-2 (E. coli) Structure
Synonym:

FGFA, Keratinocyte growth factor-2

Size Price Availability Quantity
10ug USD 160  USD160 In stock
50ug USD 440  USD440 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Human Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development. Recombinant Human FGF-10 produced in E. coli is a single, non-glycosylated polypeptide chain containing 169 amino acids.

ED50 < 20 ng/mL, measured by a cell proliferation assay using 4 MBr-5 cells, corresponding to a specific activity of > 5.0 × 104 units/mg.


Accession # O15520

Apparent Molecular Weight: ~19.3 kDa, on SDS-PAGE under reducing conditions.

Endotoxin: < 0.2 EU/μg of protein by gel clotting method

Lyophilized after extensive dialysis against PBS.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml.
Storage Stable for up to 6 months at lower than -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human FGF-10/KGF-2 (E. coli), FGFA, Keratinocyte growth factor-2 supplier, Recombinant Proteins, inhibitors, activators


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