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(Rac)-JBJ-04-125-02

Cat. No. M11415
(Rac)-JBJ-04-125-02  Structure
Synonym:

JBJ-04-125-02 racemate

Size Price Availability Quantity
5mg USD 380  USD380 In stock
10mg USD 550  USD550 In stock
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Quality Control & Documentation
Biological Activity

(Rac)-JBJ-04-125-02 is a racemate of JBJ-04-125-02, which is a potent, selectively mutated, allosteric and oral active EGFR inhibitor. The IC50 of EGFRL858R/T790M was 0.26 nM.

Chemical Information
Molecular Weight 543.61
Formula C29H26FN5O3S
CAS Number 2140807-05-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: (Rac)-JBJ-04-125-02 , JBJ-04-125-02 racemate supplier, EGFR/HER2, inhibitors, activators

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