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(R,R)-Secoisolariciresinol diglucoside

Cat. No. M11113
(R,R)-Secoisolariciresinol diglucoside Structure
Synonym:

(R,R)-SDG

Size Price Availability Quantity
20mg USD 135  USD135 In stock
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Biological Activity

(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is a minor subtype of Secoisolariciresinol diglucoside present in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) has antioxidant properties, free radical scavenging activity, and DNA-radiation protection. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by inhibiting peroxidase and chloride cycles in inflammatory cells.

Chemical Information
Molecular Weight 686.7
Formula C32H46O16
CAS Number 158932-33-3
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ralph A Pietrofesa, et al. Int J Mol Sci. Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605)

[2] Jiuling Deng, et al. Drug Des Devel Ther. A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

[3] Guiqiong Huang, et al. Int J Mol Med. Secoisolariciresinol diglucoside prevents the oxidative stress-induced apoptosis of myocardial cells through activation of the JAK2/STAT3 signaling pathway

[4] Om P Mishra, et al. Radiat Res. Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage

[5] Om P Mishra, et al. Bioorg Med Chem Lett. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)

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Keywords: (R,R)-Secoisolariciresinol diglucoside, (R,R)-SDG supplier, inhibitors, activators

 
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