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(R)-(-)-Modafinic acid

Cat. No. M5353
(R)-(-)-Modafinic acid Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

(R)-(-)-Modafinic acid(Armodafinic acid) is the major metabolite of Modafinil, which is a central nervous system vigilance promoting agent, which posseses neuroprotective properties.

Chemical Information
Molecular Weight 274.33
Formula C15H14O2S
CAS Number 112111-45-2
Solubility (25°C) 10mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Seeman P, et al. Synapse. Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil.

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