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Pyronin Y

Cat. No. M13798
Pyronin Y Structure
Synonym:

Pyronine G; C.I. 45005

Size Price Availability Quantity
100mg USD 44  USD55 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 302.8
Formula
CAS Number 92-32-0
Purity >99%
Solubility DMSO 25 mg/mL
Water 4 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Burcu Meryem Beşer, et al. Luminescence. Photophysical and photodynamic properties of Pyronin Y in micellar media at different temperatures

[2] Burcu Meryem Beşer, et al. Luminescence. Photophysics and photodynamics of Pyronin Y in n-alcohols

[3] Ayad Eddaoudi, et al. Methods Mol Biol. Flow Cytometric Detection of G0 in Live Cells by Hoechst 33342 and Pyronin Y Staining

[4] Kang Ho Kim, et al. Curr Protoc Mol Biol. Assaying Cell Cycle Status Using Flow Cytometry

[5] Allison Mayle, et al. Cytometry A. Flow cytometry analysis of murine hematopoietic stem cells

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Keywords: Pyronin Y, Pyronine G; C.I. 45005 supplier, Fluorescent Dye, inhibitors

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