Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells.
|Solubility (25°C)||DMSO 25 mg/mL
Water 4 mg/mL
|Storage||-20°C, protect from light, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Burcu Meryem Beşer, et al. Luminescence. Photophysical and photodynamic properties of Pyronin Y in micellar media at different temperatures
 Burcu Meryem Beşer, et al. Luminescence. Photophysics and photodynamics of Pyronin Y in n-alcohols
 Ayad Eddaoudi, et al. Methods Mol Biol. Flow Cytometric Detection of G0 in Live Cells by Hoechst 33342 and Pyronin Y Staining
 Kang Ho Kim, et al. Curr Protoc Mol Biol. Assaying Cell Cycle Status Using Flow Cytometry
 Allison Mayle, et al. Cytometry A. Flow cytometry analysis of murine hematopoietic stem cells
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