Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells.
|Solubility (25°C)||DMSO 25 mg/mL
Water 4 mg/mL
|Storage||-20°C, protect from light, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Fluorescent Dye Products|
Laurdan is a membrane-permeable fluorescent probe that is spectrally sensitive to the phospholipid phase of cell membranes to which it binds, and can be used for the identification of phospholipid phases, (λex=440 nm, λem=490 nm).
1,3-Diphenylisobenzofuran is a selective fluorescent probe that reacts highly specifically with a number of reactive oxygen species (e.g., singlet oxygen and hydroxyl, alkyl oxygen, or alkyl peroxy radicals), and can be used for the quantitative detection of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS), (λex=495 nm, λem=523 nm).
Sulfo-NHS-LC-Biotin sodium can label antibodies by amine reaction.
Phenol Red is a pH indicator dye that shows a distinct color change from pink to yellow in the event of a positive reaction.
Ethidium bromide is an embedded dye used for fluorescent labeling (nucleic acid staining) in molecular biology laboratory science, such as agarose gel electrophoresis.
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