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PXS-4728A

Cat. No. M9663
PXS-4728A Structure
Synonym:

BI-1467335 HCl

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
25mg USD 400  USD400 In stock
50mg USD 640  USD640 In stock
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Quality Control & Documentation
Biological Activity

PXS-4728A is a selective and orally active semicarbazide-sensitive amine oxidase (SSAO) inhibitor. PXS-4728A ameliorates chronic obstructive pulmonary disease in mice.

Chemical Information
Molecular Weight 316.80
Formula C15H22ClFN2O2
CAS Number 1478364-68-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A G Jarnicki, et al. Br J Pharmacol. The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model

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Keywords: PXS-4728A, BI-1467335 HCl supplier, Monoamine Oxidase, inhibitors, activators


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