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PSI-697

Cat. No. M14757
PSI-697 Structure
Synonym:

P-Selectin Inhibitor

Size Price Availability
5mg USD 515  USD515 1-2 Weeks
10mg USD 735  USD735 1-2 Weeks
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Biological Activity

PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.

Chemical Information
Molecular Weight 367.83
CAS Number 851546-61-7
Solubility (25°C) DMSO ≥ 45.8 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qiqi Feng, et al. Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

[2] Abdullah Kutlar, et al. Cellular adhesion and the endothelium: P-selectin

[3] Alan G Japp, et al. Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans

[4] Patricia W Bedard, et al. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

[5] Daniel D Myers Jr, et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis

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Keywords: PSI-697, P-Selectin Inhibitor supplier, inhibitors, activators

 
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