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Protocatechuic acid

Cat. No. M11202
Protocatechuic acid Structure
Synonym:

3,4-Dihydroxybenzoic acid, Protocatechuate

Size Price Availability Quantity
200mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Protocatechuic acid is a natural polyphenol that has a neuroprotective effect.

Chemical Information
Molecular Weight 154.12
Formula C7H6O4
CAS Number 99-50-3
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liyan Bai, et al. Sci Rep. Protocatechuic acid attenuates isoproterenol-induced cardiac hypertrophy via downregulation of ROCK1-Sp1-PKCγ axis

[2] Priya Upadhyay, et al. Prep Biochem Biotechnol. Protocatechuic acid production from lignin-associated phenolics

[3] Jiao Song, et al. Pharmacol Res. New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily

[4] O B Ibitoye, et al. Drug Chem Toxicol. Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2

[5] Kinga Krzysztoforska, et al. Nutr Neurosci. Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans

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Keywords: Protocatechuic acid, 3,4-Dihydroxybenzoic acid, Protocatechuate supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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