These renal pathological analyses showed that propacetamol injection induced AIKI in a subset of mice similar to those observed in APAP overdose patients.
| Cell Experiment | |
|---|---|
| Cell lines | HEK 293 cells |
| Preparation method | To investigate whether PPCM exhibits hTRPV1-activating properties, HEK 293 cells expressing wild-type hTRPV1 were examined by standard whole-cell voltage clamp experiments. Measuring ramp currents by 500-millisecond depolarizations from −100 to +100 mV, we applied PPCM at increasing concentrations (1 µM to 10 mM). |
| Concentrations | 1 µM to 10 mM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male 7-week-old BALB/c mice |
| Formulation | |
| Dosages | 600mg/kg |
| Administration | i.p. |
| Molecular Weight | 300.78 |
| Formula | C14H20N2O3.HCl |
| CAS Number | 66532-86-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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