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These renal pathological analyses showed that propacetamol injection induced AIKI in a subset of mice similar to those observed in APAP overdose patients.
| Cell Experiment | |
|---|---|
| Cell lines | HEK 293 cells |
| Preparation method | To investigate whether PPCM exhibits hTRPV1-activating properties, HEK 293 cells expressing wild-type hTRPV1 were examined by standard whole-cell voltage clamp experiments. Measuring ramp currents by 500-millisecond depolarizations from −100 to +100 mV, we applied PPCM at increasing concentrations (1 µM to 10 mM). |
| Concentrations | 1 µM to 10 mM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male 7-week-old BALB/c mice |
| Formulation | |
| Dosages | 600mg/kg |
| Administration | i.p. |
| Molecular Weight | 300.78 |
| Formula | C14H20N2O3.HCl |
| CAS Number | 66532-86-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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