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Promestriene

Cat. No. M20894
Promestriene Structure
Synonym:

3-propyl ethyl, 17B-methyl estradiol

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Biological Activity

Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application.

Chemical Information
Molecular Weight 328.49
Formula C22H32O2
CAS Number 39219-28-8
Solubility (25°C) DMSO 65 mg/mL
Water 3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liani Patricia Andrade Santos, et al. Clinics (Sao Paulo). Effects of oxytocin versus promestriene on genitourinary syndrome: a pilot, prospective, randomized, double-blind study

[2] S Palacios, et al. Climacteric. Efficacy of low-dose vaginal 17β-estradiol versus vaginal promestriene for vulvovaginal atrophy

[3] Carlos A Politano, et al. Menopause. Fractional CO2 laser versus promestriene and lubricant in genitourinary syndrome of menopause: a randomized clinical trial

[4] Lino Del Pup, et al. Anticancer Drugs. Promestriene, a specific topic estrogen. Review of 40 years of vaginal atrophy treatment: is it safe even in cancer patients?

[5] Isabel Santos, et al. Gynecol Endocrinol. Urogenital disorders associated with oestrogen deficiency: the role of promestriene as topical oestrogen therapy

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Keywords: Promestriene, 3-propyl ethyl, 17B-methyl estradiol supplier, Estrogen Receptor, inhibitors, activators


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