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Proguanil hydrochloride

Cat. No. M7819

All AbMole products are for research use only, cannot be used for human consumption.

Proguanil hydrochloride Structure

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Quality Control & Documentation
Biological Activity

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Chemical Information
Molecular Weight 290.19
Formula C11H16ClN5·HCl
CAS Number 637-32-1
Solubility (25°C) acetonitrile: water: ~1 mg/mL (60/40)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gerlinde F Plger, et al. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride

[2] G D Shanks, et al. Atovaquone and proguanil hydrochloride for prophylaxis of malaria

[3] P G Kremsner, et al. Atovaquone and proguanil hydrochloride for treatment of malaria

[4] M Beerahee. Clinical pharmacology of atovaquone and proguanil hydrochloride

[5] M Pudney, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies

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