Free shipping on all orders over $ 500

Progoitrin

Cat. No. M31155
Progoitrin Structure
Synonym:

2-hydroxy-3-butenyl glucosinolate; PRO

Size Price Availability Quantity
5mg USD 660  USD660 In stock
10mg USD 1050  USD1050 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Progoitrin (2-hydroxy-3-butenyl glucosinolate, PRO) is a naturally occurring thioglucoside with anti-thyroidal activity.

Chemical Information
Molecular Weight 389.4
Formula C11H19NO10S2
CAS Number 585-95-5
Form Solid
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shuanghua Wu, et al. Int J Mol Sci. BocODD1 and BocODD2 Regulate the Biosynthesis of Progoitrin Glucosinolate in Chinese Kale

[2] Youfeng Zhang, et al. J Agric Food Chem. Characterization of Thermally Induced Flavor Compounds from the Glucosinolate Progoitrin in Different Matrices via GC-TOF-MS

[3] Mark Grey Collett, et al. Toxins (Basel). Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits

[4] Yan Xu, et al. J Pharm Biomed Anal. Stereoselective pharmacokinetic study of epiprogoitrin and progoitrin in rats with UHPLC-MS/MS method

[5] Peter Felker, et al. Nutr Rev. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism

Related Products
Isothiuronium

Isothiouronium is a functional group, it is the acid salt of isothiourea.
Sultosilic acid, piperazine salt

Sultosilic acid piperazine salt is a compound with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically significant decrease of triglycerides, total cholesterol, beta- and pre-beta-cholesterol and an increase of alpha-cholesterol.
Ipamorelin

Ipamorelin (NNC-26-0161) is a a novel and potent ghrelin mimetic peptide compound that counteracts glucocorticoid-induced decrease in bone formation of adult rats.
PRGL493

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models.

Hercynine

Hercynine is a natural product, found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees, and is a precursor of L-(+)-ergothioneine.
  Catalog
Abmole Inhibitor Catalog




Keywords: Progoitrin, 2-hydroxy-3-butenyl glucosinolate; PRO supplier, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.