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Proglumide

Cat. No. M10420

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Proglumide Structure
Size Price Availability Quantity
50mg USD 60  USD60 In stock
100mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.

In vivo, Proglumide (250-750 mg/kg; intraperitoneal injection; adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities, cognitive dysfunctions, and cerebral oxidative stress.

Chemical Information
Molecular Weight 334.41
Formula C18H26N2O4
CAS Number 6620-60-6
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mohammad Ahmad, et al. Oxid Med Cell Longev. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus

[2] Y Iwamoto, et al. Gastroenterol Jpn. In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini

[3] M Tariq, et al. J Pharmacol Exp Ther. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats

[4] B S Bunney, et al. Ann N Y Acad Sci. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system

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