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Pro-xylane

Cat. No. M19258
Pro-xylane Structure
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Biological Activity

Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane is the first example of 'Green' chemical used in cosmetic.

Chemical Information
Molecular Weight 192.21
Formula C8H16O5
CAS Number 439685-79-7
Form Liquid
Solubility (25°C) Water 250 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Susana Raab, et al. J Drugs Dermatol. Clinical Evaluation of a Multi-Modal Facial Serum That Addresses Hyaluronic Acid Levels in Skin

[2] Anne Bouloc, et al. Acta Derm Venereol. A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study

[3] Dawei Chen, et al. Angew Chem Int Ed Engl. Probing the Catalytic Promiscuity of a Regio- and Stereospecific C-Glycosyltransferase from Mangifera indica

[4] Nathalie Pineau, et al. Eur J Dermatol. Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis

[5] Alexandre Cavezza, et al. Bioorg Med Chem Lett. Synthesis of Pro-Xylane: a new biologically active C-glycoside in aqueous media

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