Free shipping on all orders over $ 500

PR5-LL-CM01 

Cat. No. M27612

All AbMole products are for research use only, cannot be used for human consumption.

PR5-LL-CM01  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM). Anti-tumor activies.

Chemical Information
Molecular Weight 401.51
Formula C23H27N7
CAS Number 1005307-86-7
Form Solid
Solubility (25°C) DMSO 11.11 mg/mL (ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
Storage 4°C, protect from light
References

[1] Anbukkarasi Muniyandi, et al. Sci Rep. PRMT5 is a therapeutic target in choroidal neovascularization

[2] Lakshmi Prabhu, et al. Oncotarget. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Related Histone Methyltransferase Products
WDR5-IN-4

WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity.

CMP-5 dihydrochloride

CMP-5 dihydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 dihydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.

MS67 

MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM.

MS8511 

MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP).

TM2-115 

TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.

  Catalog
Abmole Inhibitor Catalog




Keywords: PR5-LL-CM01  supplier, Histone Methyltransferase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.