Polyethylenimine branched is a surfactant and a non-viral gene delivery vector rich in positively charged amine groups, which can be used in studies related to drug delivery (especially oligonucleotide delivery), and is also one of the most commonly used reagents in small- to large-scale transfection.
| Molecular Weight | 800 |
| CAS Number | 25987-06-8 |
| Storage | RT |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Paola Vicennati et al. Curr Med Chem. Polyethylenimine in medicinal chemistry
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