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Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials field. Poly(2-hydroxyethyl methacrylate) serves as the basic component of contact lenses, and is also used for soft tissue implantation, synthetic transplantation of carwrist and bone, regeneration of nervous system tissues, compound delivery, etc.
| Molecular Weight | 20000(Average) |
| CAS Number | 25249-16-5 |
| Solubility (25°C) | Ethanol ≥ 40 mg/mL |
| Storage | 2-8℃, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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