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Pimonidazole hydrochloride

Cat. No. M14755

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Pimonidazole hydrochloride Structure
Size Price Availability Quantity
10mg USD 50  USD50 In stock
25mg USD 110  USD110 In stock
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Biological Activity

Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .

Chemical Information
Molecular Weight 290.75
CAS Number 70132-51-3
Solubility (25°C) Water 5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 2-8°C, dry, sealed
References

[1] Kristina Y Aguilera, et al. Hypoxia Studies with Pimonidazole in vivo

[2] Kristine Gulliksrud, et al. Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry

[3] C B Westbury, et al. Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride

[4] Ralph E Durand, et al. The fate of hypoxic (pimonidazole-labelled) cells in human cervix tumours undergoing chemo-radiotherapy

[5] Johannes H A M Kaanders, et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer

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