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PF-06952229 

Cat. No. M28874

All AbMole products are for research use only, cannot be used for human consumption.

PF-06952229  Structure

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Quality Control & Documentation
Biological Activity

PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer.

Chemical Information
Molecular Weight 458.91
Formula C23H24ClFN4O3
CAS Number 1801333-55-0
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Brahmam Pujala, et al. Bioorg Med Chem Lett. Discovery of MDV6058 (PF-06952229), a selective and potent TGFβR1 inhibitor: Design, synthesis and optimization

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Keywords: PF-06952229  supplier, TGF-β Receptor, inhibitors, activators

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