Peptide 78, a chemotactic cytokine, consists of 78 amino acids and is a member of the IL-8 or C-X-C chemokine supergene family of proteins. peptide 78 induces neutrophils (PMN) that play an important role in rheumatoid arthritis (RA) joints. Sequence: TMRKPRSGNPDVAN.
| Molecular Weight | 1542.72 |
| Formula | C62H107N23O21S |
| CAS Number | 132116-62-2 |
| Solubility (25°C) | Water ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| Elcatonin
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| Pegmolesatide
Pegmolesatide is a synthetic peptide-based erythropoietic agent that may be used in studies related to anemia in chronic kidney disease. |
| Trofinetide
Trofinetide, a water-soluble analog of glycine-proline-glutamic acid (GPE), uses the unnatural amino acid 2-methylproline in place of the proline found in the natural compound, and works by enhancing synaptic activity, restoring synaptic structure, inhibiting the effects of inflammatory compounds in the brain, increasing antioxidant responses, reducing injury-induced cell death, and increasing central IGF-1 presence. It has neuroprotective activity and can be used in studies related to Rett syndrome. |
| Hemopressin (human, mouse)
Hemopressin is a natriuretic peptide derived from the α1 chain of hemoglobin, originally isolated from rat brain homogenates. Hemopressin is also an orally potent, selective inverse agonist at the CB1 cannabinoid receptor.Hemopressin has anti-injury sensory effects in models of inflammatory pain. |
| Trypsin Inhibitor (from Soybean)
Trypsin inhibitor is an alkaline polypeptide consisting of 58 amino acid residues with a pear shape throughout the molecule and a lysine activity center. It can compete with the activity center of many proteases for a lysyl group and inhibit their activities. |
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