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Pepinemab

Cat. No. M24915

All AbMole products are for research use only, cannot be used for human consumption.

Pepinemab Structure
Synonym:

VX 15/2503

Size Price Availability Quantity
100ug USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Pepinemab (VX 15/2503) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), also known as CD100, which is a regulator of neuronal development and plays a role in a variety of cellular processes. Pepinemab can be used in the study of various neurodegenerative diseases such as Alzheimer's disease by blocking the activity of SEMA4D.

Chemical Information
CAS Number 2097151-87-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Carlos Estevez-Fraga, et al. J Huntingtons Dis. Huntington's Disease Clinical Trials Corner: November 2022

[2] Andrew Feigin, et al. Nat Med. Publisher Correction: Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial

[3] Andrew Feigin, et al. Nat Med. Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial

[4] Alexander J Rossi, et al. Ann Surg Oncol. Pepinemab (Anti-SEMA4D) in Combination with Ipilimumab or Nivolumab for Patients with Resectable Pancreatic and Colorectal Cancer

[5] Michael R Shafique, et al. Clin Cancer Res. A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non-Small Cell Lung Cancer

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Keywords: Pepinemab, VX 15/2503 supplier, inhibitors, activators

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