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PEG400

Cat. No. M10457
PEG400 Structure
Synonym:

PEG-400; Polyethylene glycol

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100mL USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

PEG400 is a neutral and biocompatible hydrophilic polymer. PEG-400 is usually used to modify therapeutic proteins and peptides to increase their solubility.

Product Citations
Chemical Information
Molecular Weight 44.05
Formula HO(CH2CH2O)nH
CAS Number 25322-68-3
Solubility (25°C) DMSO ≥ 60 mg/mL
Water ≥ 45 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Siyuan Cao, et al. Pharmacol Res Perspect. The pharmaceutical excipient PEG400 affect the absorption of baicalein in Caco-2 monolayer model by interacting with UDP-glucuronosyltransferases and efflux transport proteins

[2] Zahra Sadri, et al. Curr Org Synth. Synthesis of Spiro1,4-Dihydropyridines: A Review

[3] Teng Gu, et al. Zhongguo Zhong Yao Za Zhi. [Effect of PEG400 on pharmacokinetics of baicalin and baicalein in gut microbiotadysbiosis rats]

[4] Yixian Zhou, et al. Acta Pharm Sin B. Mesoporous silica nanoparticles for drug and gene delivery

[5] Nawal Derkaoui, et al. J Colloid Interface Sci. PEG400 novel phase description in water

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Keywords: PEG400, PEG-400; Polyethylene glycol supplier, Solvents & Excipients, inhibitors, activators


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