PEG400 is a neutral and biocompatible hydrophilic polymer. PEG-400 is usually used to modify therapeutic proteins and peptides to increase their solubility.
Cancers (Basel). 2021 May 12;13(10):2310.
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PEG400 purchased from AbMole
| Molecular Weight | 44.05 |
| Formula | HO(CH2CH2O)nH |
| CAS Number | 25322-68-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL Water ≥ 45 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Zahra Sadri, et al. Curr Org Synth. Synthesis of Spiro1,4-Dihydropyridines: A Review
[4] Yixian Zhou, et al. Acta Pharm Sin B. Mesoporous silica nanoparticles for drug and gene delivery
[5] Nawal Derkaoui, et al. J Colloid Interface Sci. PEG400 novel phase description in water
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