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PD 168368 

Cat. No. M29125

All AbMole products are for research use only, cannot be used for human consumption.

PD 168368  Structure

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Quality Control & Documentation
Biological Activity

PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the Ki of 15–45 nM. PD 168368 is neuromedin B receptor (NMBR; IC50=96 nM) / gastrin-releasing peptide receptor (GRPR IC50=3500 nM) antagonist. PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50s of 0.57, 0.24, and 2.7 nM, respectively.

Chemical Information
Molecular Weight 554.64
Formula C31H34N6O4
CAS Number 204066-82-0
Form Solid
Solubility (25°C) DMSO 30 mg/mL (Need ultrasonic and warming)
DMF 10 mg/mL (Need ultrasonic and warming)
Storage Powder -20°C
References

[1] Gabriela Silva Monteiro de Paula, et al. J Mol Endocrinol. Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells

[2] Sarah Ehling, et al. Acta Derm Venereol. Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons

[3] Hyun-Joo Park, et al. Int J Oncol. Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells

[4] Hyun-Joo Park, et al. Cancer Lett. Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo

[5] R R Ryan, et al. J Pharmacol Exp Ther. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368

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  Catalog
Abmole Inhibitor Catalog




Keywords: PD 168368  supplier, Bombesin Receptor, inhibitors, activators

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