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PD 151746

Cat. No. M8329

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PD 151746 Structure
Synonym:

PD151746

Size Price Availability Quantity
5mg USD 72  USD72 In stock
10mg USD 120  USD120 In stock
25mg USD 240  USD240 In stock
50mg USD 380  USD380 In stock
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Biological Activity

PD151746 is a calpain inhibitor that selectively inhibits U-calpain (Ki = 0.26 ± 0.03 μM) 20 times more than m-calpain (Ki = 5.33 ± 0.77μM).

Chemical Information
Molecular Weight 237.25
Formula C11H8FNO2S
CAS Number 179461-52-0
Solubility (25°C) DMSO 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiaoying Wu, et al. Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling

[2] Hu Lei, et al. Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis

[3] Markus Meier, et al. Calpain inhibition impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling

[4] M Isabella Prn-Ares, et al. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells

[5] M K Squier, et al. Calpain and calpastatin regulate neutrophil apoptosis

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Keywords: PD 151746, PD151746 supplier, Calpain, inhibitors, activators

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