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Papain

Cat. No. M3826
Papain Structure
Synonym:

arbuz; caroid; nematolyt

Size Price Availability Quantity
100mg USD 70  USD70 In stock
500mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Papain is a cysteine protease of the peptidase C1 family.

Chemical Information
Molecular Weight 226.23
Formula C9H14N4O3
CAS Number 9001-73-4
Solubility (25°C) Soluble in water
Insoluble in most organic solvents
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Machado MN, et al. Front Physiol. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema.

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Keywords: Papain, arbuz; caroid; nematolyt supplier, Animal Modeling, inhibitors, activators


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