Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 76 mg/mL|
|Related Proton Pump Products|
Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion.
Ilaprazole sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor.
Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects.
Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.
|NEXIUM (esomeprazole magnesium)
Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion.
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